| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PolyA-specific ribonuclease PARN is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PARN |
| Gene ID: |
5073 |
| Uniprot ID: |
PARN_HUMAN |
| Specificity: |
This antibody detects endogenous levels of PARN at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human PARN |
| Post Translational Modifications | Phosphorylation by MAPKAPK2, preventing GADD45A mRNA degradation after genotoxic stress. |
| Function | 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization. Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability. |
| Protein Name | Poly(A-Specific Ribonuclease ParnDeadenylating NucleaseDeadenylation NucleasePolyadenylate-Specific Ribonuclease |
| Database Links | Reactome: R-HSA-380994Reactome: R-HSA-429947Reactome: R-HSA-450604 |
| Cellular Localisation | NucleusCytoplasmNucleolusSome Nuclear Fraction Is Nucleolar |
| Alternative Antibody Names | Anti-Poly(A-Specific Ribonuclease Parn antibodyAnti-Deadenylating Nuclease antibodyAnti-Deadenylation Nuclease antibodyAnti-Polyadenylate-Specific Ribonuclease antibodyAnti-PARN antibodyAnti-DAN antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
