| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PANX2 |
| Gene ID: | 56666 |
| Uniprot ID: | PANX2_HUMAN |
| Immunogen Region: | 320-480 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 320-480 of human PANX2 (NP_443071.2). |
| Immunogen Sequence: | FIFDKLHKVGIKTRRQWRRS QFCDINILAMFCNENRDHIK SLNRLDFITNESDLMYDNVV RQLLAALAQSNHDATPTVRD SGVQTVDPSANPAEPDGAAE PPVVKRPRKKMKWIPTSNPL PQPFKEPLAIMRVENSKAEK PKPARRKTATDTLIAPLLDR S |
| Post Translational Modifications | S-palmitoylated in neural stem and progenitor cells. Cleaved by CASP3 and CASP7 during apoptosis. Cleavage has no effect on it function. |
| Function | Ion channel with a slight anion preference. Also able to release ATP. Plays a role in regulating neurogenesis and apoptosis in keratinocytes. |
| Protein Name | Pannexin-2 |
| Database Links | Reactome: R-HSA-112303 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneEndoplasmic Reticulum MembraneLocalizes To Golgi Apparatus And Endoplasmic Reticulum In Multipotential Neural Stem And Progenitor Cells And To Plasma Membrane In Terminally Differentiated Neurons |
| Alternative Antibody Names | Anti-Pannexin-2 antibodyAnti-PANX2 antibody |
Information sourced from Uniprot.org