• Western blot analysis of extracts of various cell lines, using PANX2 antibody (STJ114170) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.

Anti-PANX2 antibody (320-480) (STJ114170)

SKU:
STJ114170

£112.50 - £524.50
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PANX2
Gene ID: 56666
Uniprot ID: PANX2_HUMAN
Immunogen Region: 320-480
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 320-480 of human PANX2 (NP_443071.2).
Immunogen Sequence: FIFDKLHKVGIKTRRQWRRS QFCDINILAMFCNENRDHIK SLNRLDFITNESDLMYDNVV RQLLAALAQSNHDATPTVRD SGVQTVDPSANPAEPDGAAE PPVVKRPRKKMKWIPTSNPL PQPFKEPLAIMRVENSKAEK PKPARRKTATDTLIAPLLDR S
Post Translational Modifications S-palmitoylated in neural stem and progenitor cells. Cleaved by CASP3 and CASP7 during apoptosis. Cleavage has no effect on it function.
Function Ion channel with a slight anion preference. Also able to release ATP. Plays a role in regulating neurogenesis and apoptosis in keratinocytes.
Protein Name Pannexin-2
Database Links Reactome: R-HSA-112303
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Golgi Apparatus Membrane
Endoplasmic Reticulum Membrane
Localizes To Golgi Apparatus And Endoplasmic Reticulum In Multipotential Neural Stem And Progenitor Cells And To Plasma Membrane In Terminally Differentiated Neurons
Alternative Antibody Names Anti-Pannexin-2 antibody
Anti-PANX2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance