||WB, IHC-P, ELISA
||Human, Mouse, Rat
||Rabbit polyclonal anti-PAK5 antibody is suitable for use in Western Blot, Immunohistochemistry and ELISA.
||FOR RESEARCH USE ONLY (RUO).
||Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
||The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.
||Store at-20°C, and avoid repeat freeze-thaw cycles.
||WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000
||PAK5 polyclonal antibody detects endogenous levels of PAK5 protein.
||Synthesized peptide derived from human PAK5
||630-710 aa, C-terminal
| Post Translational Modifications || Autophosphorylated when activated by CDC42/p21. |
| Function || Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. |
| Protein Name || Serine/Threonine-Protein Kinase Pak 5P21-Activated Kinase 5Pak-5P21-Activated Kinase 7Pak-7 |
| Database Links || Reactome: R-HSA-428540 |
| Cellular Localisation || MitochondrionCytoplasmNucleusShuttles Between The Nucleus And The MitochondriaAnd Mitochondrial Localization Is Essential For The Role In Cell Survival |
| Alternative Antibody Names || Anti-Serine/Threonine-Protein Kinase Pak 5 antibodyAnti-P21-Activated Kinase 5 antibodyAnti-Pak-5 antibodyAnti-P21-Activated Kinase 7 antibodyAnti-Pak-7 antibodyAnti-PAK5 antibodyAnti-KIAA1264 antibodyAnti-PAK7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance