• Immunohistochemistryt analysis of paraffin-embedded human brain, using PAK7 Antibody. The lane on the right is blocked with the PAK7 peptide.
  • Western blot analysis of 3T3 cells using PAK5 Polyclonal Antibody
  • Western blot analysis of PAK7 Antibody. The lane on the right is blocked with the PAK7 peptide.
  • Western blot analysis of various cells using PAK5 Polyclonal Antibody

Anti-PAK5 antibody (STJ94938)

SKU:
STJ94938

Current Stock:
Host: Rabbit
Applications: WB, IHC-P, ELISA
Reactivity: Human, Mouse, Rat
Short Description: Rabbit polyclonal anti-PAK5 antibody is suitable for use in Western Blot, Immunohistochemistry and ELISA.
Note: FOR RESEARCH USE ONLY (RUO).
Clonality: Polyclonal
Conjugation: Unconjugated
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.
Storage Instruction: Store at-20°C, and avoid repeat freeze-thaw cycles.
Concentration: 1 mg/ml
Isotype: IgG
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Specificity: PAK5 polyclonal antibody detects endogenous levels of PAK5 protein.
Uniprot ID: PAK5_HUMAN
Gene ID: 57144
Gene Symbol: PAK5
Immunogen: Synthesized peptide derived from human PAK5
Immunogen Region: 630-710 aa, C-terminal
Post Translational Modifications Autophosphorylated when activated by CDC42/p21.
Function Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
Protein Name Serine/Threonine-Protein Kinase Pak 5
P21-Activated Kinase 5
Pak-5
P21-Activated Kinase 7
Pak-7
Database Links Reactome: R-HSA-428540
Cellular Localisation Mitochondrion
Cytoplasm
Nucleus
Shuttles Between The Nucleus And The Mitochondria
And Mitochondrial Localization Is Essential For The Role In Cell Survival
Alternative Antibody Names Anti-Serine/Threonine-Protein Kinase Pak 5 antibody
Anti-P21-Activated Kinase 5 antibody
Anti-Pak-5 antibody
Anti-P21-Activated Kinase 7 antibody
Anti-Pak-7 antibody
Anti-PAK5 antibody
Anti-KIAA1264 antibody
Anti-PAK7 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance