| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PAK5 (600-700) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PAK5 |
| Gene ID: |
57144 |
| Uniprot ID: |
PAK5_HUMAN |
| Immunogen Region: |
600-700 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 600-700 of human PAK5 (NP_065074.1). |
| Immunogen Sequence: |
RKSLVGTPYWMAPEVISRLP YGTEVDIWSLGIMVIEMIDG EPPYFNEPPLQAMRRIRDSL PPRVKDLHKVSSVLRGFLDL MLVREPSQRATAQELLGHPF L |
| Tissue Specificity | Predominantly expressed in brain. |
| Post Translational Modifications | Autophosphorylated when activated by CDC42/p21. |
| Function | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. |
| Protein Name | Serine/Threonine-Protein Kinase Pak 5P21-Activated Kinase 5Pak-5P21-Activated Kinase 7Pak-7 |
| Database Links | Reactome: R-HSA-428540Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013405Reactome: R-HSA-9013407 |
| Cellular Localisation | MitochondrionCytoplasmNucleusShuttles Between The Nucleus And The MitochondriaAnd Mitochondrial Localization Is Essential For The Role In Cell Survival |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Pak 5 antibodyAnti-P21-Activated Kinase 5 antibodyAnti-Pak-5 antibodyAnti-P21-Activated Kinase 7 antibodyAnti-Pak-7 antibodyAnti-PAK5 antibodyAnti-KIAA1264 antibodyAnti-PAK7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
