| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
P2RX2 |
| Gene ID: |
22953 |
| Uniprot ID: |
P2RX2_HUMAN |
| Immunogen Region: |
60-320 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 60-320 of human P2RX2 (NP_733782.1). |
| Immunogen Sequence: |
VFIVQKSYQESETGPESSII TKVKGITTSEHKVWDVEEYV KPPEGGSVFSIITRVEATHS QTQGTCPESIRVHNATCLSD ADCVAGELDMLGNGLRTGRC VPYYQGPSKTCEVFGWCPVE DGASVSQFLGTMAPNFTILI KNSIHYPKFHFSKGNIADRT DGYLKRCTFHEASDLYCPIF KLGFIVEKAGESFTELAHKG GVIGVIINWDCDLDLPASEC NPKYSFRRLDPKHVPASSG |
| Tissue Specificity | Expressed in both the central and peripheral nervous system, as well as in the pituitary gland. |
| Function | ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle. |
| Protein Name | P2x Purinoceptor 2P2x2Atp ReceptorPurinergic Receptor |
| Database Links | Reactome: R-HSA-139853Reactome: R-HSA-418346 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLocalizes To The Apical Membranes Of Hair Cells In The Organ Of Corti |
| Alternative Antibody Names | Anti-P2x Purinoceptor 2 antibodyAnti-P2x2 antibodyAnti-Atp Receptor antibodyAnti-Purinergic Receptor antibodyAnti-P2RX2 antibodyAnti-P2X2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
