| Short Description : | Rabbit polyclonal P2RX2 (60-320) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | P2RX2 |
| Gene ID: | 22953 |
| Uniprot ID: | P2RX2_HUMAN |
| Immunogen Region: | 60-320 |
| Immunogen Sequence: | VFIVQKSYQESETGPESSII TKVKGITTSEHKVWDVEEYV KPPEGGSVFSIITRVEATHS QTQGTCPESIRVHNATCLSD ADCVAGELDMLGNGLRTGRC VPYYQGPSKTCEVFGWCPVE DGASVSQFLGTMAPNFTILI KNSIHYPKFHFSKGNIADRT DGYLKRCTFHEASDLYCPIF KLGFIVEKAGESFTELAHKG GVIGVIINWDCDLDLPASEC NPKYSFRRLDPKHVPASSG |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-320 of human P2RX2 (NP_733782.1). |
| Tissue Specificity | Expressed in both the central and peripheral nervous system, as well as in the pituitary gland. |
| Function | ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle. |
| Protein Name | P2x Purinoceptor 2P2x2Atp ReceptorPurinergic Receptor |
| Database Links | Reactome: R-HSA-139853Reactome: R-HSA-418346 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLocalizes To The Apical Membranes Of Hair Cells In The Organ Of Corti |
| Alternative Antibody Names | Anti-P2x Purinoceptor 2 antibodyAnti-P2x2 antibodyAnti-Atp Receptor antibodyAnti-Purinergic Receptor antibodyAnti-P2RX2 antibodyAnti-P2X2 antibody |
Information sourced from Uniprot.org
