| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-OXCT1 (261-520) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
OXCT1 |
| Gene ID: |
5019 |
| Uniprot ID: |
SCOT1_HUMAN |
| Immunogen Region: |
261-520 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 261-520 of human OXCT1 (NP_000427.1). |
| Immunogen Sequence: |
IPQIYVHRLIKGEKYEKRIE RLSIRKEGDGEAKSAKPGDD VRERIIKRAALEFEDGMYAN LGIGIPLLASNFISPNITVH LQSENGVLGLGPYPRQHEAD ADLINAGKETVTILPGASFF SSDESFAMIRGGHVDLTMLG AMQVSKYGDLANWMIPGKMV KGMGGAMDLVSSAKTKVVVT MEHSAKGNAHKIMEKCTLPL TGKQCVNRIITEKAVFDVDK KKGLTLIELWEGLTVDDVQ |
| Tissue Specificity | Abundant in heart, followed in order by brain, kidney, skeletal muscle, and lung, whereas in liver it is undetectable. Expressed (at protein level) in all tissues (except in liver), most abundant in myocardium, then brain, kidney, adrenal glands, skeletal muscle and lung.also detectable in leukocytes and fibroblasts. |
| Function | Key enzyme for ketone body catabolism. Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA. Acetoacetyl-CoA is further metabolized by acetoacetyl-CoA thiolase into two acetyl-CoA molecules which enter the citric acid cycle for energy production. Forms a dimeric enzyme where both of the subunits are able to form enzyme-CoA thiolester intermediates, but only one subunit is competent to transfer the CoA moiety to the acceptor carboxylate (3-oxo acid) and produce a new acyl-CoA. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. |
| Protein Name | Succinyl-Coa -3-Ketoacid Coenzyme A Transferase 1 - MitochondrialScot3-Oxoacid Coa-Transferase 1Somatic-Type Succinyl-Coa -3-Oxoacid Coa-TransferaseScot-SSuccinyl-Coa -3-Oxoacid Coa Transferase |
| Database Links | Reactome: R-HSA-77108 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Succinyl-Coa -3-Ketoacid Coenzyme A Transferase 1 - Mitochondrial antibodyAnti-Scot antibodyAnti-3-Oxoacid Coa-Transferase 1 antibodyAnti-Somatic-Type Succinyl-Coa -3-Oxoacid Coa-Transferase antibodyAnti-Scot-S antibodyAnti-Succinyl-Coa -3-Oxoacid Coa Transferase antibodyAnti-OXCT1 antibodyAnti-OXCT antibodyAnti-SCOT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
