Anti-OXCT1 antibody (261-520) (STJ110438)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal OXCT1 (261-520) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OXCT1 |
| Gene ID | 5019 |
| Uniprot ID | SCOT1_HUMAN |
| Immunogen Region | 261-520 |
| Immunogen Sequence | IPQIYVHRLIKGEKYEKRIE RLSIRKEGDGEAKSAKPGDD VRERIIKRAALEFEDGMYAN LGIGIPLLASNFISPNITVH LQSENGVLGLGPYPRQHEAD ADLINAGKETVTILPGASFF SSDESFAMIRGGHVDLTMLG AMQVSKYGDLANWMIPGKMV KGMGGAMDLVSSAKTKVVVT MEHSAKGNAHKIMEKCTLPL TGKQCVNRIITEKAVFDVDK KKGLTLIELWEGLTVDDVQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 261-520 of human OXCT1 (NP_000427.1). |
Additional Info
| Tissue Specificity | Abundant in heart, followed in order by brain, kidney, skeletal muscle, and lung, whereas in liver it is undetectable. Expressed (at protein level) in all tissues (except in liver), most abundant in myocardium, then brain, kidney, adrenal glands, skeletal muscle and lung.also detectable in leukocytes and fibroblasts. |
| Function | Key enzyme for ketone body catabolism. Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA. Acetoacetyl-CoA is further metabolized by acetoacetyl-CoA thiolase into two acetyl-CoA molecules which enter the citric acid cycle for energy production. Forms a dimeric enzyme where both of the subunits are able to form enzyme-CoA thiolester intermediates, but only one subunit is competent to transfer the CoA moiety to the acceptor carboxylate (3-oxo acid) and produce a new acyl-CoA. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. |
| Protein Name | Succinyl-Coa -3-Ketoacid Coenzyme A Transferase 1 - MitochondrialScot3-Oxoacid Coa-Transferase 1Somatic-Type Succinyl-Coa -3-Oxoacid Coa-TransferaseScot-SSuccinyl-Coa -3-Oxoacid Coa Transferase |
| Database Links | Reactome: R-HSA-77108Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Succinyl-Coa -3-Ketoacid Coenzyme A Transferase 1 - Mitochondrial antibodyAnti-Scot antibodyAnti-3-Oxoacid Coa-Transferase 1 antibodyAnti-Somatic-Type Succinyl-Coa -3-Oxoacid Coa-Transferase antibodyAnti-Scot-S antibodyAnti-Succinyl-Coa -3-Oxoacid Coa Transferase antibodyAnti-OXCT1 antibodyAnti-OXCT antibodyAnti-SCOT antibody |
Information sourced from Uniprot.org