Anti-Orexin B antibody (N-Term) (STJA0040680)
SPECIFICATIONS
ClonalityPolyclonal
HostChicken
ConjugationUnconjugated
IsotypeIgY
ImmunogenA peptide from the N-terminus of human Orexin B (1-14 aa).
General Information
| Short Description | Chicken polyclonal anti-Orexin B (N-Term) for use in ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Chicken |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgY |
| Conjugation | Unconjugated |
| Purification | Affinity-purified |
| Formulation | PBS with 0.02% sodium azide. |
| Storage Instruction | Short term storage at 2-8°C for one week. At-20°C as an undiluted liquid for up to 12 months. |
Target Information
| Gene Symbol | HCRT |
| Gene ID | 3060 |
| Uniprot ID | OREX_HUMAN |
| Immunogen | A peptide from the N-terminus of human Orexin B (1-14 aa). |
| Immunogen Region | N-Term |
| Immunogen Sequence | Human |
| Specificity | Human Orexin B (1-14) : Affinity purified. |
Additional Info
| Tissue Specificity | Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Post Translational Modifications | Specific enzymatic cleavages at paired basic residues yield the different active peptides. |
| Function | Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A: Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner. Orexin-B: Binds to orexin receptor HCRTR2/OX2R only. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner. |
| Protein Name | Hypocretin Neuropeptide PrecursorHypocretinHcrtOrexin PrecursorPrepro-OrexinPreprohypocretin Cleaved Into - Orexin-AHypocretin-1Hcrt1 - Orexin-BHypocretin-2Hcrt2 |
| Database Links | Reactome: R-HSA-389397Reactome: R-HSA-416476 |
| Cellular Localisation | Rough Endoplasmic ReticulumCytoplasmic VesicleSynapseAssociated With Perikaryal Rough Endoplasmic Reticulum As Well As Cytoplasmic Large Granular Vesicles At Synapses |
| Alternative Antibody Names | Anti-Hypocretin Neuropeptide Precursor antibodyAnti-Hypocretin antibodyAnti-Hcrt antibodyAnti-Orexin Precursor antibodyAnti-Prepro-Orexin antibodyAnti-Preprohypocretin Cleaved Into - Orexin-A antibodyAnti-Hypocretin-1 antibodyAnti-Hcrt1 - Orexin-B antibodyAnti-Hypocretin-2 antibodyAnti-Hcrt2 antibodyAnti-HCRT antibodyAnti-OX antibodyAnti-PPORX antibodyAnti-PPOX antibody |
Information sourced from Uniprot.org