| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ORC2 |
| Gene ID: | 4999 |
| Uniprot ID: | ORC2_HUMAN |
| Immunogen Region: | 458-577 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 458-577 of human ORC2 (NP_006181.1). |
| Immunogen Sequence: | TSYENSLLVKQSGSLPLSSL THVLRSLTPNARGIFRLLIK YQLDNQDNPSYIGLSFQDFY QQCREAFLVNSDLTLRAQLT EFRDHKLIRTKKGTDGVEYL LIPVDNGTLTDFLEKEEEEA |
| Function | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. |
| Protein Name | Origin Recognition Complex Subunit 2 |
| Database Links | Reactome: R-HSA-113507Reactome: R-HSA-176187Reactome: R-HSA-68616Reactome: R-HSA-68689Reactome: R-HSA-68867Reactome: R-HSA-68949Reactome: R-HSA-68962 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Origin Recognition Complex Subunit 2 antibodyAnti-ORC2 antibodyAnti-ORC2L antibody |
Information sourced from Uniprot.org