Anti-OPRL1 antibody (270-370) (STJ28144)

Name: Anti-OPRL1 antibody (270-370) (STJ28144)
SKU: STJ28144
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ28144

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Short Description	Rabbit polyclonal OPRL1 (270-370) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	OPRL1
Gene ID	4987
Uniprot ID	OPRX_HUMAN
Immunogen Region	270-370
Immunogen Sequence	AVFVGCWTPVQVFVLAQGLG VQPSSETAVAILRFCTALGY VNSCLNPILYAFLDENFKAC FRKFCCASALRRDVQVSDRV RSIAKDVALACKTSETVPRP A
Specificity	A synthetic peptide corresponding to a sequence within amino acids 270-370 of human OPRL1 (NP_000904.1)

Tissue Specificity	Detected in blood leukocytes.
Post Translational Modifications	Phosphorylation at Ser-363 requires GRK3.
Function	G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
Protein Name	Nociceptin Receptor Kappa-Type 3 Opioid Receptor Kor-3 Orphanin Fq Receptor
Database Links	Reactome: R-HSA-375276 Reactome: R-HSA-418594
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Cytoplasmic Vesicle Ligand Binding Leads To Receptor Internalization Into Cytoplasmic Vesicles Decreasing The Amount Of Available Receptor At The Cell Surface Internalization Requires Phosphorylation At Ser-363 Can Recycle To The Cell Membrane
Alternative Antibody Names	Anti-Nociceptin Receptor antibody Anti-Kappa-Type 3 Opioid Receptor antibody Anti-Kor-3 antibody Anti-Orphanin Fq Receptor antibody Anti-OPRL1 antibody Anti-OOR antibody Anti-ORL1 antibody

Information sourced from Uniprot.org