Host: | Rabbit |
Applications: | WB/IHC-P/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Monoclonal |
Clone ID : | S6MR |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000IHC-P:1:100-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | OGG1 |
Gene ID: | 4968 |
Uniprot ID: | OGG1_HUMAN |
Immunogen Region: | 246-345 |
Specificity: | A synthetic peptide corresponding to a sequence within amino acids 246-345 of human OGG1 (O15527). |
Immunogen Sequence: | VGTKVADCICLMALDKPQAV PVDVHMWHIAQRDYSWHPTT SQAKGPSPQTNKELGNFFRS LWGPYAGWAQAVLFSADLRQ SRHAQEPPAKRRKGSKGPEG |
Tissue Specificity | Ubiquitous. |
Function | DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. |
Protein Name | N-Glycosylase/Dna Lyase Includes - 8-Oxoguanine Dna Glycosylase - Dna-(Apurinic Or Apyrimidinic Site LyaseAp Lyase |
Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-110330Reactome: R-HSA-110331Reactome: R-HSA-110357Reactome: R-HSA-5649702Reactome: R-HSA-9656255Reactome: R-HSA-9656256Reactome: R-HSA-9657050 O15527-4 |
Cellular Localisation | NucleusNucleoplasmNucleus SpeckleNucleus MatrixTogether With Apex1 Is Recruited To Nuclear Speckles In Uva-Irradiated CellsIsoform 1a: NucleusIsoform 2a: Mitochondrion |
Alternative Antibody Names | Anti-N-Glycosylase/Dna Lyase Includes - 8-Oxoguanine Dna Glycosylase - Dna-(Apurinic Or Apyrimidinic Site Lyase antibodyAnti-Ap Lyase antibodyAnti-OGG1 antibodyAnti-MMH antibodyAnti-MUTM antibodyAnti-OGH1 antibody |
Information sourced from Uniprot.org