• Immunohistochemistry analysis of OGG1 in paraffin-embedded rat brain using OGG1 Rabbit monoclonal antibody (STJ11102216) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Western blot analysis of lysates from Mouse testis, using OGG1 Rabbit monoclonal antibody (STJ11102216) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 3min.
  • Western blot analysis of various lysates using OGG1 Rabbit monoclonal antibody (STJ11102216) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-OGG1 antibody (246-345) [S6MR] (STJ11102216)

SKU:
STJ11102216

£146.50 - £639.50
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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-OGG1 (246-345) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: S6MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: OGG1
Gene ID: 4968
Uniprot ID: OGG1_HUMAN
Immunogen Region: 246-345
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 246-345 of human OGG1 (O15527).
Immunogen Sequence: VGTKVADCICLMALDKPQAV PVDVHMWHIAQRDYSWHPTT SQAKGPSPQTNKELGNFFRS LWGPYAGWAQAVLFSADLRQ SRHAQEPPAKRRKGSKGPEG
Tissue Specificity Ubiquitous.
Function DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
Protein Name N-Glycosylase/Dna Lyase Includes - 8-Oxoguanine Dna Glycosylase - Dna-(Apurinic Or Apyrimidinic Site Lyase
Ap Lyase
Database Links Reactome: R-HSA-110328
Reactome: R-HSA-110329
Reactome: R-HSA-110330
Reactome: R-HSA-110331
Reactome: R-HSA-110357
Reactome: R-HSA-5649702
Reactome: R-HSA-9656255
Reactome: R-HSA-9656256
Reactome: R-HSA-9657050 O15527-4
Cellular Localisation Nucleus
Nucleoplasm
Nucleus Speckle
Nucleus Matrix
Together With Apex1 Is Recruited To Nuclear Speckles In Uva-Irradiated Cells
Isoform 1a: Nucleus
Isoform 2a: Mitochondrion
Alternative Antibody Names Anti-N-Glycosylase/Dna Lyase Includes - 8-Oxoguanine Dna Glycosylase - Dna-(Apurinic Or Apyrimidinic Site Lyase antibody
Anti-Ap Lyase antibody
Anti-OGG1 antibody
Anti-MMH antibody
Anti-MUTM antibody
Anti-OGH1 antibody

Information sourced from Uniprot.org

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