Anti-OBSCN antibody (STJA0008462)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human OBSCN
General Information
| Short Description | Rabbit polyclonal anti-Obscurin for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OBSCNUniprot ID=OBSCN_HUMAN" |
| Immunogen | Synthesized peptide derived from human OBSCN |
| Specificity | This antibody detects endogenous levels of OBSCN at Human |
Additional Info
| Function | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle. Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1. Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). |
| Protein Name | ObscurinObscurin-RhogefObscurin-Myosin Light Chain KinaseObscurin-Mlck |
| Cellular Localisation | Isoform 3: CytoplasmMyofibrilSarcomereM LineCytoplasmZ LineIn Differentiating Skeletal Muscle CellsIsoform 3 Primarily Localizes To The Sarcomeric M-Line And Less Frequently To The Z-DiskIsoform 3 Colocalizes With Ank1 Isoform Mu17/Ank15 At The M-Line In Differentiated Skeletal Muscle CellsCell MembraneSarcolemmaNucleusColocalizes With Cdh2 And Atp1b1 To The Sarcolemma And To Intercalating Disks In Cardiac MusclesColocalizes With Atp1b1 To M Line And Z Line In Cardiac Muscles |
| Alternative Antibody Names | Anti-Obscurin antibodyAnti-Obscurin-Rhogef antibodyAnti-Obscurin-Myosin Light Chain Kinase antibodyAnti-Obscurin-Mlck antibodyAnti-OBSCN antibodyAnti-KIAA1556 antibodyAnti-KIAA1639 antibody |
Information sourced from Uniprot.org