| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NUDT18 |
| Gene ID: |
79873 |
| Uniprot ID: |
NUD18_HUMAN |
| Immunogen Region: |
1-323 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human NUDT18 (NP_079091.3). |
| Immunogen Sequence: |
MASEGLAGALASVLAGQGSS VHSCDSAPAGEPPAPVRLRK NVCYVVLAVFLSEQDEVLLI QEAKRECRGSWYLPAGRMEP GETIVEALQREVKEEAGLHC EPETLLSVEERGPSWVRFVF LARPTGGILKTSKEADAESL QAAWYPRTSLPTPLRAHDIL HLVELAAQYRQQARHPLILP QELPCDLVCQRLVATFTSAQ TVWVLVGTVGMPHLPVTACG LDPMEQRGGMKMAVLRLLQ |
| Function | Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. |
| Protein Name | 8-Oxo-Dgdp Phosphatase Nudt182-Hydroxy-Dadp Phosphatase7 -8-Dihydro-8-Oxoguanine PhosphataseMutt Homolog 3Nucleoside Diphosphate-Linked Moiety X Motif 18Nudix Motif 18 |
| Database Links | Reactome: R-HSA-2393930 Q6ZVK8-1 |
| Alternative Antibody Names | Anti-8-Oxo-Dgdp Phosphatase Nudt18 antibodyAnti-2-Hydroxy-Dadp Phosphatase antibodyAnti-7 -8-Dihydro-8-Oxoguanine Phosphatase antibodyAnti-Mutt Homolog 3 antibodyAnti-Nucleoside Diphosphate-Linked Moiety X Motif 18 antibodyAnti-Nudix Motif 18 antibodyAnti-NUDT18 antibodyAnti-MTH3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and ERCC1 knockout (KO) HeLa cells, using [KO Validated] ERCC1 Rabbit polyclonal antibody (STJ11100039) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89111/357565/STJ11100039_1__56308.1713121691.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and ERCC1 knockout (KO) HeLa cells, using [KO Validated] ERCC1 Rabbit polyclonal antibody (STJ11100039) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.")
