| Function | May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP. Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives. Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear. Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs. May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA. Exhibits decapping activity towards dpCoA-capped RNAs in vitro. |
| Protein Name | Nucleotide Triphosphate Diphosphatase Nudt15Mutt Homolog 2Mth2Nucleoside Diphosphate-Linked Moiety X Motif 15Nudix Motif 15Nucleoside Diphosphate-Linked To Another Moiety X Hydrolase 15Nudix Hydrolase 15 |
| Database Links | Reactome: R-HSA-2393930Reactome: R-HSA-9748787 |
| Alternative Antibody Names | Anti-Nucleotide Triphosphate Diphosphatase Nudt15 antibodyAnti-Mutt Homolog 2 antibodyAnti-Mth2 antibodyAnti-Nucleoside Diphosphate-Linked Moiety X Motif 15 antibodyAnti-Nudix Motif 15 antibodyAnti-Nucleoside Diphosphate-Linked To Another Moiety X Hydrolase 15 antibodyAnti-Nudix Hydrolase 15 antibodyAnti-NUDT15 antibodyAnti-MTH2 antibody |
Information sourced from Uniprot.org
