| Post Translational Modifications | Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Autophosphorylation is also possible at Thr-208. |
| Function | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway. |
| Protein Name | Nuak Family Snf1-Like Kinase 2Omphalocele Kinase 2Snf1/Amp Kinase-Related KinaseSnark |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Nuak Family Snf1-Like Kinase 2 antibodyAnti-Omphalocele Kinase 2 antibodyAnti-Snf1/Amp Kinase-Related Kinase antibodyAnti-Snark antibodyAnti-NUAK2 antibodyAnti-OMPHK2 antibodyAnti-SNARK antibody |
Information sourced from Uniprot.org
