| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NTSR1 (1-70) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NTSR1 |
| Gene ID: |
4923 |
| Uniprot ID: |
NTR1_HUMAN |
| Immunogen Region: |
1-70 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human NTSR1 (NP_002522.2). |
| Immunogen Sequence: |
MRLNSSAPGTPGTPAADPFQ RAQAGLEEALLAPGFGNASG NASERVLAAPSSELDVNTDI YSKVLVTAVY |
| Tissue Specificity | Expressed in prostate (at protein level). Detected in colon and peripheral blood mononuclear cells. Detected at very low levels in brain. |
| Post Translational Modifications | N-glycosylated. Palmitoylated.this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment. |
| Function | G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis. |
| Protein Name | Neurotensin Receptor Type 1Nt-R-1Ntr1High-Affinity Levocabastine-Insensitive Neurotensin ReceptorNtrh |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMembrane RaftPalmitoylation Is Required For Localization At Cav1-Enriched Membrane Rafts |
| Alternative Antibody Names | Anti-Neurotensin Receptor Type 1 antibodyAnti-Nt-R-1 antibodyAnti-Ntr1 antibodyAnti-High-Affinity Levocabastine-Insensitive Neurotensin Receptor antibodyAnti-Ntrh antibodyAnti-NTSR1 antibodyAnti-NTRR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
