Anti-NSMF antibody (226-505) (STJ24737)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NSMF (226-505) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NSMF |
| Gene ID | 26012 |
| Uniprot ID | NSMF_HUMAN |
| Immunogen Region | 226-505 |
| Immunogen Sequence | FQTATTTMQANFRKHLRMVG SRRVKAQTFAERRERSFSRS WSDPTPMKADTSHDSRDSSD LQSSHCTLDEAFEDLDWDTE KGLEAVACDTEGFVPPKVML ISSKVPKAEYIPTIIRRDDP SIIPILYDHEHATFEDILEE IERKLNVYHKGAKIWKMLIF CQGGPGHLYLLKNKVATFAK VEKEEDMIHFWKRLSRLMSK VNPEPNVIHIMGCYILGNPN GEKLFQNLRTLMTPYRVTF |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 226-505 of human NSMF (NP_001124443.1). |
Additional Info
| Tissue Specificity | Highly expressed in adult and fetal brain. Weakly expressed in heart, liver, spleen, testis, small intestine, skeletal muscle, peripheral white blood cells and kidney. |
| Post Translational Modifications | Proteolytically processed after NMDA receptor activation. Cleaved in a calcium-dependent and calpain-sensitive manner. Calpain cleavage is essential for the translocation process from dendrites to the nucleus. |
| Function | Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells. |
| Protein Name | Nmda Receptor Synaptonuclear Signaling And Neuronal Migration FactorNasal Embryonic Luteinizing Hormone-Releasing Hormone FactorNasal Embryonic Lhrh Factor |
| Database Links | |
| Cellular Localisation | NucleusNucleus EnvelopeNucleus MembraneNucleus MatrixCytoplasmCell CortexCytoskeletonCell MembranePeripheral Membrane ProteinCell ProjectionDendriteSynapseSynaptosomePostsynaptic DensityMembraneFound On The Outside Of The Luteinizing-Hormone-Releasing Hormone (Lhrh) Cell Membrane And Axons Projecting From The Olfactory Pit And EpitheliumAssociates With Transcriptionally Active Chromatin RegionsDetected At The Nuclear Membranes Of Ca1 NeuronsCortical CytoskeletonLocalized In Proximal Apical DendritesColocalizes With Cabp1 In Dendrites And Dendritic SpinesMyristoylation Is A Prerequisite For Extranuclear LocalizationTranslocates From Dendrites To The Nucleus During Nmda Receptor-Dependent Long-Term Potentiation (Ltp) Induction Of Synaptic Transmission At Schaffer Collateral/Ca1 Synapses Of Hippocampal Primary Neurons And In A Importin-Dependent Manner |
| Alternative Antibody Names | Anti-Nmda Receptor Synaptonuclear Signaling And Neuronal Migration Factor antibodyAnti-Nasal Embryonic Luteinizing Hormone-Releasing Hormone Factor antibodyAnti-Nasal Embryonic Lhrh Factor antibodyAnti-NSMF antibodyAnti-NELF antibody |
Information sourced from Uniprot.org