| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Non-structural maintenance of chromosomes element 3 homolog (110-190 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NSMCE3 |
| Gene ID: |
56160 |
| Uniprot ID: |
NSE3_HUMAN |
| Immunogen Region: |
110-190 aa |
| Specificity: |
MAGG1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 110-190 |
| Function | Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest. |
| Protein Name | Non-Structural Maintenance Of Chromosomes Element 3 HomologNon-Smc Element 3 HomologHepatocellular Carcinoma-Associated Protein 4Mage-G1 AntigenMelanoma-Associated Antigen G1Necdin-Like Protein 2 |
| Database Links | Reactome: R-HSA-3108214 |
| Cellular Localisation | CytoplasmNucleusChromosomeTelomere |
| Alternative Antibody Names | Anti-Non-Structural Maintenance Of Chromosomes Element 3 Homolog antibodyAnti-Non-Smc Element 3 Homolog antibodyAnti-Hepatocellular Carcinoma-Associated Protein 4 antibodyAnti-Mage-G1 Antigen antibodyAnti-Melanoma-Associated Antigen G1 antibodyAnti-Necdin-Like Protein 2 antibodyAnti-NSMCE3 antibodyAnti-HCA4 antibodyAnti-MAGEG1 antibodyAnti-NDNL2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
