| Short Description : | Rabbit polyclonal WHSC1L1 (400-600) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NSD3 |
| Gene ID: | 54904 |
| Uniprot ID: | NSD3_HUMAN |
| Immunogen Region: | 400-600 |
| Immunogen Sequence: | EEALSQAKKSVASKTEVKKT RRPRSVLNTQPEQTNAGEVA SSLSSTEIRRHSQRRHTSAE EEEPPPVKIAWKTAAARKSL PASITMHKGSLDLQKCNMSP VVKIEQVFALQNATGDGKFI DQFVYSTKGIGNKTEISVRG QDRLIISTPNQRNEKPTQSV SSPEATSGSTGSVEKKQQRR SIRTRSESEKSTEVVPKKKI K |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-600 of human NSD3/NSD3/WHSC1L1 (NP_060248.2). |
| Tissue Specificity | Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung. |
| Function | Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. |
| Protein Name | Histone-Lysine N-Methyltransferase Nsd3Nuclear Set Domain-Containing Protein 3Protein WhistleWhsc1-Like 1 Isoform 9 With Methyltransferase Activity To LysineWolf-Hirschhorn Syndrome Candidate 1-Like Protein 1Whsc1-Like Protein 1 |
| Database Links | Reactome: R-HSA-3214841 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Nsd3 antibodyAnti-Nuclear Set Domain-Containing Protein 3 antibodyAnti-Protein Whistle antibodyAnti-Whsc1-Like 1 Isoform 9 With Methyltransferase Activity To Lysine antibodyAnti-Wolf-Hirschhorn Syndrome Candidate 1-Like Protein 1 antibodyAnti-Whsc1-Like Protein 1 antibodyAnti-NSD3 antibodyAnti-WHSC1L1 antibodyAnti-DC28 antibody |
Information sourced from Uniprot.org
