Anti-NRXN1 antibody (260-340 aa) (STJ191055)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 260-340
General Information
| Short Description | Rabbit polyclonal anti-Neurexin-1-beta (260-340 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NRXN1 |
| Gene ID | 9378 |
| Uniprot ID | NRX1B_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 260-340 |
| Immunogen Region | 260-340 aa |
| Specificity | NRX1B Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Neuronal cell surface protein involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. Plays a role in formation of synaptic junctions. Functions as part of a trans-synaptic complex by binding to cerebellins and postsynaptic GRID1. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN1B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic NMDAR response. |
| Protein Name | Neurexin-1-BetaNeurexin I-Beta |
| Database Links | Reactome: R-HSA-6794361Reactome: R-HSA-3000171 |
| Cellular Localisation | Presynaptic Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Neurexin-1-Beta antibodyAnti-Neurexin I-Beta antibodyAnti-NRXN1 antibody |
Information sourced from Uniprot.org