| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NRG4 |
| Gene ID: | 145957 |
| Uniprot ID: | NRG4_HUMAN |
| Immunogen Region: | 84-95 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NRG4 (NP_612640.1). |
| Immunogen Sequence: | MPTDHEEPCGPSHKSFCLNG GLCYVIPTIPSPFCRCVENY TGARCEEVFLPGSSIQTKSN LFEAFVALAVLVTLIIGAFY FLCRKGHFQRASSVQYDINL |
| Post Translational Modifications | Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. Extensive glycosylation precedes the proteolytic cleavage. |
| Function | Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. |
| Protein Name | Pro-Neuregulin-4 - Membrane-Bound IsoformPro-Nrg4 Cleaved Into - Neuregulin-4Nrg-4 |
| Database Links | Reactome: R-HSA-1227986Reactome: R-HSA-1236394Reactome: R-HSA-1250196Reactome: R-HSA-1250342Reactome: R-HSA-1250347Reactome: R-HSA-1251985Reactome: R-HSA-1257604Reactome: R-HSA-1963640Reactome: R-HSA-1963642Reactome: R-HSA-2219530Reactome: R-HSA-5673001Reactome: R-HSA-6785631Reactome: R-HSA-6811558Reactome: R-HSA-8847993Reactome: R-HSA-8863795Reactome: R-HSA-9664565Reactome: R-HSA-9665686 |
| Cellular Localisation | Pro-Neuregulin-4Membrane-Bound Isoform: Cell MembraneSingle-Pass Type I Membrane ProteinDoes Not Seem To Be ActiveNeuregulin-4: Secreted |
| Alternative Antibody Names | Anti-Pro-Neuregulin-4 - Membrane-Bound Isoform antibodyAnti-Pro-Nrg4 Cleaved Into - Neuregulin-4 antibodyAnti-Nrg-4 antibodyAnti-NRG4 antibody |
Information sourced from Uniprot.org