Anti-NRG4 antibody (84-95) (STJ24820)

Name: Anti-NRG4 antibody (84-95) (STJ24820)
SKU: STJ24820
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ24820

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Short Description	Rabbit polyclonal NRG4 (84-95) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	NRG4
Gene ID	145957
Uniprot ID	NRG4_HUMAN
Immunogen Region	84-95
Immunogen Sequence	MPTDHEEPCGPSHKSFCLNG GLCYVIPTIPSPFCRCVENY TGARCEEVFLPGSSIQTKSN LFEAFVALAVLVTLIIGAFY FLCRKGHFQRASSVQYDINL
Specificity	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NRG4 (NP_612640.1).

Post Translational Modifications	Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. Extensive glycosylation precedes the proteolytic cleavage.
Function	Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
Protein Name	Pro-Neuregulin-4 - Membrane-Bound Isoform Pro-Nrg4 Cleaved Into - Neuregulin-4 Nrg-4
Database Links	Reactome: R-HSA-1227986 Reactome: R-HSA-1236394 Reactome: R-HSA-1250196 Reactome: R-HSA-1250342 Reactome: R-HSA-1250347 Reactome: R-HSA-1251985 Reactome: R-HSA-1257604 Reactome: R-HSA-1963640 Reactome: R-HSA-1963642 Reactome: R-HSA-2219530 Reactome: R-HSA-5673001 Reactome: R-HSA-6785631 Reactome: R-HSA-6811558 Reactome: R-HSA-8847993 Reactome: R-HSA-8863795 Reactome: R-HSA-9664565 Reactome: R-HSA-9665686
Cellular Localisation	Pro-Neuregulin-4 Membrane-Bound Isoform: Cell Membrane Single-Pass Type I Membrane Protein Does Not Seem To Be Active Neuregulin-4: Secreted
Alternative Antibody Names	Anti-Pro-Neuregulin-4 - Membrane-Bound Isoform antibody Anti-Pro-Nrg4 Cleaved Into - Neuregulin-4 antibody Anti-Nrg-4 antibody Anti-NRG4 antibody

Information sourced from Uniprot.org