| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NRF1 (1-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NRF1 |
| Gene ID: |
4899 |
| Uniprot ID: |
NRF1_HUMAN |
| Immunogen Region: |
1-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NRF1 (NP_001035199.1). |
| Immunogen Sequence: |
MEEHGVTQTEHMATIEAHAV AQQVQQVHVATYTEHSMLSA DEDSPSSPEDTSYDDSDILN STAADEVTAHLAAAGPVGMA AAAAVATGKKRKRPHVFESN PSIRKRQQTRLLRKLRATLD EYTTRVGQQAIVLCISPSKP NPVFKVFGAAPLENVVRKYK SMILEDLESALAEHAPAPQE VNSELPPLTIDGIPVSVDKM TQAQLRAFIPEMLKYSTGRG KPGWGKESCKPIWWPEDIP |
| Tissue Specificity | Ubiquitously expressed with strongest expression in skeletal muscle. |
| Post Translational Modifications | Phosphorylation enhances DNA binding. |
| Function | Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. |
| Protein Name | Nuclear Respiratory Factor 1Nrf-1Alpha Palindromic-Binding ProteinAlpha-Pal |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-2151201 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Respiratory Factor 1 antibodyAnti-Nrf-1 antibodyAnti-Alpha Palindromic-Binding Protein antibodyAnti-Alpha-Pal antibodyAnti-NRF1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
