| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Mineralocorticoid receptor (10-90 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NR3C2 |
| Gene ID: |
4306 |
| Uniprot ID: |
MCR_HUMAN |
| Immunogen Region: |
10-90 aa |
| Specificity: |
MCR Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 10-90 |
| Post Translational Modifications | Phosphorylated. |
| Function | Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. |
| Protein Name | Mineralocorticoid ReceptorMrNuclear Receptor Subfamily 3 Group C Member 2 |
| Database Links | Reactome: R-HSA-3371497Reactome: R-HSA-383280Reactome: R-HSA-4090294 |
| Cellular Localisation | CytoplasmNucleusEndoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic And Nuclear In The Absence Of LigandNuclear After Ligand-BindingWhen Bound To Hsd11b2It Is Found Associated With The Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Mineralocorticoid Receptor antibodyAnti-Mr antibodyAnti-Nuclear Receptor Subfamily 3 Group C Member 2 antibodyAnti-NR3C2 antibodyAnti-MCR antibodyAnti-MLR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
