| Host: | Rabbit |
| Applications: | WB/IF/ICC/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NR1I3 |
| Gene ID: | 9970 |
| Uniprot ID: | NR1I3_HUMAN |
| Immunogen Region: | 103-352 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 103-352 of human NR1I3 (NP_001070948.1). |
| Immunogen Sequence: | PVQLSKEQEELIRTLLGAHT RHMGTMFEQFVQFRPPAHLF IHHQPLPTLAPVLPLVTHFA DINTFMVLQVIKFTKDLPVF RSLPIEDQISLLKGAAVEIC HIVLNTTFCLQTQNFLCGPL RYTIEDGARVSPTVGFQVEF LELLFHFHGTLRKLQLQEPE YVLLAAMALFSPDRPGVTQR DEIDQLQEEMALTLQSYIKG QQRRPRDRFLYAKLLGLLAE LRSINEAYGYQIQHIQGLS |
| Tissue Specificity | Predominantly expressed in liver. |
| Post Translational Modifications | Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation. |
| Function | Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. |
| Protein Name | Nuclear Receptor Subfamily 1 Group I Member 3Constitutive Activator Of Retinoid ResponseConstitutive Active ResponseConstitutive Androstane ReceptorCarOrphan Nuclear Receptor Mb67 |
| Database Links | Reactome: R-HSA-383280 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonRecruited To The Cytoplasm By Dnajc7 |
| Alternative Antibody Names | Anti-Nuclear Receptor Subfamily 1 Group I Member 3 antibodyAnti-Constitutive Activator Of Retinoid Response antibodyAnti-Constitutive Active Response antibodyAnti-Constitutive Androstane Receptor antibodyAnti-Car antibodyAnti-Orphan Nuclear Receptor Mb67 antibodyAnti-NR1I3 antibodyAnti-CAR antibody |
Information sourced from Uniprot.org
