| Host: | Rabbit |
| Applications: | WB/IF/ICC/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500 IF/ICC:1:50-1:200 IP:0.5 Mu g-4 Mu g antibody for 400 Mu g-600 Mu g extracts of whole cells ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NR1I2 |
| Gene ID: | 8856 |
| Uniprot ID: | NR1I2_HUMAN |
| Immunogen Region: | 135-230 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 135-230 of human PXR (NP_003880.3). |
| Immunogen Sequence: | TQPLGVQGLTEEQRMMIREL MDAQMKTFDTTFSHFKNFRL PGVLSSGCELPESLQAPSRE EAAKWSQVRKDLCSLKVSLQ LRGEDGSVWNYKPPAD |
| Tissue Specificity | Expressed in liver, colon and small intestine. |
| Function | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. |
| Protein Name | Nuclear Receptor Subfamily 1 Group I Member 2 Orphan Nuclear Receptor Par1 Orphan Nuclear Receptor Pxr Pregnane X Receptor Steroid And Xenobiotic Receptor Sxr |
| Database Links | Reactome: R-HSA-383280 Reactome: R-HSA-4090294 O75469-1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Subfamily 1 Group I Member 2 antibody Anti-Orphan Nuclear Receptor Par1 antibody Anti-Orphan Nuclear Receptor Pxr antibody Anti-Pregnane X Receptor antibody Anti-Steroid And Xenobiotic Receptor antibody Anti-Sxr antibody Anti-NR1I2 antibody Anti-PXR antibody |
Information sourced from Uniprot.org