Anti-NR1I2 antibody (135-230) (STJ119280)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PXR (135-230) antibody for use in WB, IF, ICC, IP and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/IP/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500IF/ICC:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 400 Mu g-600 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NR1I2 |
| Gene ID | 8856 |
| Uniprot ID | NR1I2_HUMAN |
| Immunogen Region | 135-230 |
| Immunogen Sequence | TQPLGVQGLTEEQRMMIREL MDAQMKTFDTTFSHFKNFRL PGVLSSGCELPESLQAPSRE EAAKWSQVRKDLCSLKVSLQ LRGEDGSVWNYKPPAD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 135-230 of human PXR (NP_003880.3). |
Additional Info
| Tissue Specificity | Expressed in liver, colon and small intestine. |
| Function | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. |
| Protein Name | Nuclear Receptor Subfamily 1 Group I Member 2Orphan Nuclear Receptor Par1Orphan Nuclear Receptor PxrPregnane X ReceptorSteroid And Xenobiotic ReceptorSxr |
| Database Links | Reactome: R-HSA-383280Reactome: R-HSA-4090294 O75469-1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Subfamily 1 Group I Member 2 antibodyAnti-Orphan Nuclear Receptor Par1 antibodyAnti-Orphan Nuclear Receptor Pxr antibodyAnti-Pregnane X Receptor antibodyAnti-Steroid And Xenobiotic Receptor antibodyAnti-Sxr antibodyAnti-NR1I2 antibodyAnti-PXR antibody |
Information sourced from Uniprot.org