| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NPSR1 |
| Gene ID: | 387129 |
| Uniprot ID: | NPSR1_HUMAN |
| Immunogen Region: | C-Term |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human NPSR1 (NP_001287863.1). |
| Immunogen Sequence: | SKAKIKAIKYSIIIILAFIC CWSPYFLFDILDNFNLLPDT QERFYASVIIQNLPALNSAI NPLIYCVFSSSISFPCREQR SQDSRMTFRERTERHEMQIL SKPEFI |
| Tissue Specificity | Isoform 4 is ubiquitous.it is detected in glandular epithelia of bronchus, stomach, small intestine, colon, uterus, esophagus, spleen, kidney, pancreas, prostate and breast. Isoform 1 is detected in uterus, colon and prostate, and in the smooth muscle cell layer in bronchial and arterial walls (at protein level). Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients.whereas in epithelial cells, its expression is consistently stronger in asthma patients. |
| Function | G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases. |
| Protein Name | Neuropeptide S Receptor G-Protein Coupled Receptor 154 G-Protein Coupled Receptor Pgr14 G-Protein Coupled Receptor For Asthma Susceptibility |
| Database Links | Reactome: R-HSA-375276 Reactome: R-HSA-416476 Reactome: R-HSA-418555 |
| Cellular Localisation | Isoform 1: Cell Membrane Multi-Pass Membrane Protein Isoform 3: Cell Membrane Isoform 4: Cell Membrane Isoform 2: Cytoplasm Isoform 5: Cytoplasm Isoform 6: Cytoplasm Isoform 7: Cytoplasm Isoform 9: Cytoplasm |
| Alternative Antibody Names | Anti-Neuropeptide S Receptor antibody Anti-G-Protein Coupled Receptor 154 antibody Anti-G-Protein Coupled Receptor Pgr14 antibody Anti-G-Protein Coupled Receptor For Asthma Susceptibility antibody Anti-NPSR1 antibody Anti-GPR154 antibody Anti-GPRA antibody Anti-PGR14 antibody |
Information sourced from Uniprot.org