| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NPC1L1 (1030-1100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NPC1L1 |
| Gene ID: |
29881 |
| Uniprot ID: |
NPCL1_HUMAN |
| Immunogen Region: |
1030-1100 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1030-1100 of human Niemann-Pick type C1 Like-1 (NP_001095118.1). |
| Immunogen Sequence: |
AAYSTSVNLTSDGQVLASRF MAYHKPLKNSQDYTEALRAA RELAANITADLRKVPGTDPA FEVFPYTITNV |
| Tissue Specificity | Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle. |
| Post Translational Modifications | Highly glycosylated. |
| Function | Plays a major role in cholesterol homeostasis. Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia. May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation. May be involved in caveolin trafficking from the plasma membrane. In addition, acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation. |
| Protein Name | Npc1-Like Intracellular Cholesterol Transporter 1Npc1l1Niemann-Pick C1-Like Protein 1 |
| Database Links | Reactome: R-HSA-8963678 Q9UHC9-2 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmic Vesicle MembraneSubfractionation Of Brush Border Membranes From Proximal Enterocytes Suggests Considerable Association With The Apical Membrane FractionExists As A Predominantly Cell Surface Membrane Expressed ProteinLocalizes In A Subcellular Vesicular Compartment Rich In Rab5 |
| Alternative Antibody Names | Anti-Npc1-Like Intracellular Cholesterol Transporter 1 antibodyAnti-Npc1l1 antibodyAnti-Niemann-Pick C1-Like Protein 1 antibodyAnti-NPC1L1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
