| Short Description : | Rabbit polyclonal NOXA1 (140-300) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NOXA1 |
| Gene ID: | 10811 |
| Uniprot ID: | NOXA1_HUMAN |
| Immunogen Region: | 140-300 |
| Immunogen Sequence: | EAASSLREAMSKWPEGSLNG LDSALDQVQRRGSLPPRQVP RGEVFRPHRWHLKHLEPVDF LGKAKVVASAIPDDQGWGVR PQQPQGPGANHDARSLIMDS PRAGTHQGPLDAETEVGADR CTSTAYQEQRPQVEQVGKQA PLSPGLPAMGGPGPGPCEDP A |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 140-300 of human NOXA1 (NP_006638.1). |
| Tissue Specificity | Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon. |
| Post Translational Modifications | Interaction with YWHAZ depends on phosphorylation by PKA. |
| Function | Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. |
| Protein Name | Nadph Oxidase Activator 1Nox Activator 1Antigen Ny-Co-31Ncf2-Like ProteinP67phox-Like FactorP51-Nox |
| Database Links | Reactome: R-HSA-5668599Reactome: R-HSA-9013149Reactome: R-HSA-9013423Reactome: R-HSA-9673324 |
| Cellular Localisation | CytoplasmCell MembraneTranslocation To Membranes Depends On Noxo1 Or Ncf1 And Maybe Rac1 |
| Alternative Antibody Names | Anti-Nadph Oxidase Activator 1 antibodyAnti-Nox Activator 1 antibodyAnti-Antigen Ny-Co-31 antibodyAnti-Ncf2-Like Protein antibodyAnti-P67phox-Like Factor antibodyAnti-P51-Nox antibodyAnti-NOXA1 antibodyAnti-P51NOX antibody |
Information sourced from Uniprot.org
