| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/FC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-NOXA (Internal) is suitable for use in ELISA, Western Blot and Flow Cytometry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 16kDa band observed in Human Bone Marrow lysates and in lysates of cell line LNCaP and in preliminary testing of Human Cerebellum lysate and Peripheral blood monocyte cell lysat |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
PMAIP1 |
| Gene ID: |
5366 |
| Uniprot ID: |
APR_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_066950.1 |
| Immunogen Sequence: |
TQLRRFGDKLNFRQK |
| Function | Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. |
| Protein Name | Phorbol-12-Myristate-13-Acetate-Induced Protein 1Pma-Induced Protein 1Immediate-Early-Response Protein AprProtein Noxa |
| Database Links | Reactome: R-HSA-111448Reactome: R-HSA-111453Reactome: R-HSA-6803204 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Phorbol-12-Myristate-13-Acetate-Induced Protein 1 antibodyAnti-Pma-Induced Protein 1 antibodyAnti-Immediate-Early-Response Protein Apr antibodyAnti-Protein Noxa antibodyAnti-PMAIP1 antibodyAnti-NOXA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
