Host: | Goat |
Applications: | Pep-ELISA/WB/FC |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Goat polyclonal antibody anti-NOXA (Internal) is suitable for use in ELISA, Western Blot and Flow Cytometry research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Concentration: | 0.5 mg/mL |
Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 16kDa band observed in Human Bone Marrow lysates and in lysates of cell line LNCaP and in preliminary testing of Human Cerebellum lysate and Peripheral blood monocyte cell lysat |
Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Gene Symbol: | PMAIP1 |
Gene ID: | 5366 |
Uniprot ID: | APR_HUMAN |
Immunogen Region: | Internal |
Accession Number: | NP_066950.1 |
Immunogen Sequence: | TQLRRFGDKLNFRQK |
Function | Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. |
Protein Name | Phorbol-12-Myristate-13-Acetate-Induced Protein 1Pma-Induced Protein 1Immediate-Early-Response Protein AprProtein Noxa |
Database Links | Reactome: R-HSA-111448Reactome: R-HSA-111453Reactome: R-HSA-6803204 |
Cellular Localisation | Mitochondrion |
Alternative Antibody Names | Anti-Phorbol-12-Myristate-13-Acetate-Induced Protein 1 antibodyAnti-Pma-Induced Protein 1 antibodyAnti-Immediate-Early-Response Protein Apr antibodyAnti-Protein Noxa antibodyAnti-PMAIP1 antibodyAnti-NOXA antibody |
Information sourced from Uniprot.org