| Host: |
Goat |
| Applications: |
Pep-ELISA/IHC |
| Reactivity: |
Human/Mouse/Rat/Dog/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-NOLC1 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
IHC-Recommended concentration, 2-4µg/mlELISA-antibody detection limit dilution 1:16000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
NOLC1 |
| Gene ID: |
9221 |
| Uniprot ID: |
NOLC1_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_004732.2 |
| Immunogen Sequence: |
QVNSIKFDSE |
| Function | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities. |
| Protein Name | Nucleolar And Coiled-Body Phosphoprotein 1140 Kda Nucleolar PhosphoproteinNopp140Hepatitis C Virus Ns5a-Transactivated Protein 13Hcv Ns5a-Transactivated Protein 13Nucleolar 130 Kda ProteinNucleolar Phosphoprotein P130 |
| Cellular Localisation | NucleusNucleolusCytoplasmShuttles Between The Nucleolus And The CytoplasmAt Telophase It Begins To Assemble Into Granular-Like Pre-Nucleolar Bodies Which Are Subsequently Relocated To Nucleoli At The Early G1-Phase |
| Alternative Antibody Names | Anti-Nucleolar And Coiled-Body Phosphoprotein 1 antibodyAnti-140 Kda Nucleolar Phosphoprotein antibodyAnti-Nopp140 antibodyAnti-Hepatitis C Virus Ns5a-Transactivated Protein 13 antibodyAnti-Hcv Ns5a-Transactivated Protein 13 antibodyAnti-Nucleolar 130 Kda Protein antibodyAnti-Nucleolar Phosphoprotein P130 antibodyAnti-NOLC1 antibodyAnti-KIAA0035 antibodyAnti-NS5ATP13 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
