| Function | Plays an essential role as an potent mitigator of inflammation. Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways. Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway. In turn, promotes bacterial tolerance. Inhibits also the DDX58-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked DDX58 activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked DDX58 degradation. Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue. |
| Protein Name | Nacht - Lrr And Pyd Domains-Containing Protein 12Monarch-1Pyrin-Containing Apaf1-Like Protein 7Pypaf7 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Nacht - Lrr And Pyd Domains-Containing Protein 12 antibodyAnti-Monarch-1 antibodyAnti-Pyrin-Containing Apaf1-Like Protein 7 antibodyAnti-Pypaf7 antibodyAnti-Nlrp12 antibodyAnti-NALP12 antibody |
Information sourced from Uniprot.org
