Anti-NKX3-1 antibody (1-50) (STJ94507)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human NKX3-1. AA range:1-50
General Information
| Short Description | Rabbit polyclonal anti-Homeobox protein Nkx-3.1 (1-50) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NKX3-1 |
| Gene ID | 4824 |
| Uniprot ID | NKX31_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NKX3-1. AA range:1-50 |
| Immunogen Region | 1-50 |
| Specificity | Nkx-3.1 Polyclonal Antibody detects endogenous levels of Nkx-3.1 protein. |
Additional Info
| Tissue Specificity | Highly expressed in the prostate and, at a lower level, in the testis. |
| Post Translational Modifications | Ubiquitinated by TOPORS.monoubiquitinated at several residues and also polyubiquitinated on single residues. |
| Function | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGTAG-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. |
| Protein Name | Homeobox Protein Nkx-3.1Homeobox Protein Nk-3 Homolog A |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Nkx-3.1 antibodyAnti-Homeobox Protein Nk-3 Homolog A antibodyAnti-NKX3-1 antibodyAnti-NKX3.1 antibodyAnti-NKX3A antibody |
Information sourced from Uniprot.org