• Anti-NGFR antibody [MRQ-21] (STJ16100403)

Anti-NGFR antibody [MRQ-21] (STJ16100403)

SKU:
STJ16100403

£1,781.50
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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-NGFR is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: MRQ-21
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Dilution Range: IHC 1:100 – 1:500
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: NGFR
Gene ID: 4804
Uniprot ID: TNR16_HUMAN
Post Translational Modifications N- and O-glycosylated. O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. Phosphorylated on serine residues.
Function Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF. Plays an important role in differentiation and survival of specific neuronal populations during development. Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA. Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 16
Gp80-Lngfr
Low Affinity Neurotrophin Receptor P75ntr
Low-Affinity Nerve Growth Factor Receptor
Ngf Receptor
P75 Icd
Cd Antigen Cd271
Database Links Reactome: R-HSA-193634
Reactome: R-HSA-193648
Reactome: R-HSA-193670
Reactome: R-HSA-193681
Reactome: R-HSA-193692
Reactome: R-HSA-205017
Reactome: R-HSA-205025
Reactome: R-HSA-205043
Reactome: R-HSA-209543
Reactome: R-HSA-209560
Reactome: R-HSA-209563
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Perikaryon
Cell Projection
Growth Cone
Dendritic Spine
Alternative Antibody Names Anti-Tumor Necrosis Factor Receptor Superfamily Member 16 antibody
Anti-Gp80-Lngfr antibody
Anti-Low Affinity Neurotrophin Receptor P75ntr antibody
Anti-Low-Affinity Nerve Growth Factor Receptor antibody
Anti-Ngf Receptor antibody
Anti-P75 Icd antibody
Anti-Cd Antigen Cd271 antibody
Anti-NGFR antibody
Anti-TNFRSF16 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance