• Immunohistochemistry analysis of Neuropilin-1 antibody in paraffin-embedded human brain tissue.
  • Western blot analysis of lysate from HepG2 cells, using Neuropilin-1 antibody.
  • Western blot analysis of various cells using Neuropilin-1 Polyclonal Antibody

Anti-Neuropilin-1 antibody (STJ94438)

SKU:
STJ94438

Current Stock:
Host: Rabbit
Applications: WB, IHC-P, ELISA
Reactivity: Human, Mouse, Rat
Short Description: Rabbit polyclonal anti-Neuropilin-1 antibody is suitable for use in Western Blot, Immunohistochemistry and ELISA.
Note: FOR RESEARCH USE ONLY (RUO).
Clonality: Polyclonal
Conjugation: Unconjugated
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.
Storage Instruction: Store at-20°C, and avoid repeat freeze-thaw cycles.
Concentration: 1 mg/ml
Isotype: IgG
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
Specificity: Neuropilin-1 polyclonal antibody detects endogenous levels of Neuropilin-1 protein.
Uniprot ID: NRP1_HUMAN
Gene ID: 8829
Gene Symbol: NRP1
Immunogen: Synthesized peptide derived from human Neuropilin-1.
Immunogen Region: Internal
Function Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR. Isoform 2: Binds VEGF-165 and may inhibit its binding to cells. May induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. (Microbial infection) Acts as a host factor for human coronavirus SARS-CoV-2 infection. Recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection.
Protein Name Neuropilin-1
Vascular Endothelial Cell Growth Factor 165 Receptor
Cd Antigen Cd304
Database Links Reactome: R-HSA-194306
Reactome: R-HSA-376176
Reactome: R-HSA-399954
Reactome: R-HSA-399955
Reactome: R-HSA-399956
Reactome: R-HSA-445144
Reactome: R-HSA-447041
Cellular Localisation Isoform 2: Secreted
Mitochondrion Membrane
Single-Pass Type I Membrane Protein
Cell Membrane
Cytoplasm
Alternative Antibody Names Anti-Neuropilin-1 antibody
Anti-Vascular Endothelial Cell Growth Factor 165 Receptor antibody
Anti-Cd Antigen Cd304 antibody
Anti-NRP1 antibody
Anti-NRP antibody
Anti-VEGF165R antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance