Host: | Rabbit |
Applications: | WB/IF |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-NET1 (1-300) is suitable for use in Western Blot and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | NET1 |
Gene ID: | 10276 |
Uniprot ID: | ARHG8_HUMAN |
Immunogen Region: | 1-300 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NET1 (NP_001040625.1). |
Immunogen Sequence: | MEPELAAQKQPRPRRRSRRA SGLSTEGATGPSADTSGSEL DGRCSLRRGSSFTFLTPGPN WDFTLKRKRREKDDDVVSLS SLDLKEPSNKRVRPLARVTS LANLISPVRNGAVRRFGQTI QSFTLRGDHRSPASAQKFSS RSTVPTPAKRRSSALWSEML DITMKESLTTREIRRQEAIY EMSRGEQDLIEDLKLARKAY HDPMLKLSIMSEEELTHIFG DLDSYIPLHEDLLTRIGEA |
Tissue Specificity | Widely expressed. |
Function | Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. |
Protein Name | Neuroepithelial Cell-Transforming Gene 1 Protein Proto-Oncogene P65 Net1 Rho Guanine Nucleotide Exchange Factor 8 |
Database Links | Reactome: R-HSA-193648 Reactome: R-HSA-416482 Reactome: R-HSA-8980692 Reactome: R-HSA-9013026 |
Cellular Localisation | Cytoplasm Nucleus |
Alternative Antibody Names | Anti-Neuroepithelial Cell-Transforming Gene 1 Protein antibody Anti-Proto-Oncogene P65 Net1 antibody Anti-Rho Guanine Nucleotide Exchange Factor 8 antibody Anti-NET1 antibody Anti-ARHGEF8 antibody |
Information sourced from Uniprot.org