| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NEK3 |
| Gene ID: | 4752 |
| Uniprot ID: | NEK3_HUMAN |
| Immunogen Region: | 267-506 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 267-506 of human NEK3 (NP_689933.1). |
| Immunogen Sequence: | PEIIMEYGEEVLEEIKNSKH NTPRKKTNPSRIRIALGNEA STVQEEEQDRKGSHTDLESI NENLVESALRRVNREEKGNK SVHLRKASSPNLHRRQWEKN VPNTALTALENASILTSSLT AEDDRGGSVIKYSKNTTRKQ WLKETPDTLLNILKNADLSL AFQTYTIYRPGSEGFLKGPL SEETEASDSVDGGHDSVILD PERLEPGLDEEDTDFEEEDD NPDWVSELKKRAGWQGLCD |
| Tissue Specificity | Up-regulated in malignant versus normal breast tissue. Isoform 2 shows a high level of expression in testis, ovary and brain. |
| Post Translational Modifications | Phosphorylation at Thr-479 regulates its catalytic activity. |
| Function | Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2. |
| Protein Name | Serine/Threonine-Protein Kinase Nek3Hspk 36Never In Mitosis A-Related Kinase 3Nima-Related Protein Kinase 3 |
| Cellular Localisation | CytoplasmCell ProjectionAxon |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Nek3 antibodyAnti-Hspk 36 antibodyAnti-Never In Mitosis A-Related Kinase 3 antibodyAnti-Nima-Related Protein Kinase 3 antibodyAnti-NEK3 antibody |
Information sourced from Uniprot.org