Anti-NEK1 antibody (280-360 aa) (STJ191365)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 280-360
General Information
| Short Description | Rabbit polyclonal anti-Serine/threonine-protein kinase Nek1 (280-360 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NEK1 |
| Gene ID | 4750 |
| Uniprot ID | NEK1_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 280-360 |
| Immunogen Region | 280-360 aa |
| Specificity | NEK1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis. Involved in cilium assembly. |
| Protein Name | Serine/Threonine-Protein Kinase Nek1Never In Mitosis A-Related Kinase 1Nima-Related Protein Kinase 1Renal Carcinoma Antigen Ny-Ren-55 |
| Database Links | Reactome: R-HSA-9861718 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeAssociated With The Pericentriolar MaterialLocalizes To Centrosome During Interphase And MitosisTranslocated From Cytoplasm To Discrete Nuclear Foci At Sites Of Dna Damage |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Nek1 antibodyAnti-Never In Mitosis A-Related Kinase 1 antibodyAnti-Nima-Related Protein Kinase 1 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-55 antibodyAnti-NEK1 antibodyAnti-KIAA1901 antibody |
Information sourced from Uniprot.org