| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NECTIN3 |
| Gene ID: |
25945 |
| Uniprot ID: |
NECT3_HUMAN |
| Immunogen Region: |
127-366 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 127-366 of human PVRL3 (NP_001230215.1). |
| Immunogen Sequence: |
SLNDATITLHNIGFSDSGKY ICKAVTFPLGNAQSSTTVTV LVEPTVSLIKGPDSLIDGGN ETVAAICIAATGKPVAHIDW EGDLGEMESTTTSFPNETAT IISQYKLFPTRFARGRRITC VVKHPALEKDIRYSFILDIQ YAPEVSVTGYDGNWFVGRKG VNLKCNADANPPPFKSVWSR LDGQWPDGLLASDNTLHFVH PLTFNYSGVYICKVTNSLGQ RSDQKVIYISAYNSVASLN |
| Tissue Specificity | Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines. |
| Function | Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN1: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types. Plays a role in the morphology of the ciliary body. |
| Protein Name | Nectin-3Cdw113Nectin Cell Adhesion Molecule 3Poliovirus Receptor-Related Protein 3Cd Antigen Cd113 |
| Database Links | Reactome: R-HSA-418990Reactome: R-HSA-420597 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinPostsynaptic Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionAdherens JunctionIn The Auditory EpitheliumSpecificaly Localizes To The Apical Side Of The Lateral Membranes Of Supporting Cells |
| Alternative Antibody Names | Anti-Nectin-3 antibodyAnti-Cdw113 antibodyAnti-Nectin Cell Adhesion Molecule 3 antibodyAnti-Poliovirus Receptor-Related Protein 3 antibodyAnti-Cd Antigen Cd113 antibodyAnti-NECTIN3 antibodyAnti-PRR3 antibodyAnti-PVRL3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
