| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Protein NDRG4 (187-236) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NDRG4 |
| Gene ID: |
65009 |
| Uniprot ID: |
NDRG4_HUMAN |
| Immunogen Region: |
187-236 |
| Specificity: |
NDRG4 Polyclonal Antibody detects endogenous levels of NDRG4 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human NDRG4. AA range:187-236 |
| Tissue Specificity | Expressed predominantly in brain and heart (at protein level). In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells. |
| Post Translational Modifications | Phosphorylated in an aortic smooth muscle cell line, following PDGF treatment. |
| Function | Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress. May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. |
| Protein Name | Protein Ndrg4Brain Development-Related Molecule 1N-Myc Downstream-Regulated Gene 4 ProteinVascular Smooth Muscle Cell-Associated Protein 8Smap-8 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Protein Ndrg4 antibodyAnti-Brain Development-Related Molecule 1 antibodyAnti-N-Myc Downstream-Regulated Gene 4 Protein antibodyAnti-Vascular Smooth Muscle Cell-Associated Protein 8 antibodyAnti-Smap-8 antibodyAnti-NDRG4 antibodyAnti-BDM1 antibodyAnti-KIAA1180 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
