| Tissue Specificity | Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis. |
| Post Translational Modifications | NCOA4 levels may be regulated via HERC2-mediated ubiquitination leading to proteosomal degradation.HERC2 association is dependent on NCOA4 iron occupancy. |
| Function | Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis. Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy. Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion. Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation. In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. Another study shows only weak behavior as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR. Binds to DNA replication origins, binding is not restricted to sites of active transcription and may likely be independent from the nuclear receptor transcriptional coactivator function. May inhibit activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex. |
| Protein Name | Nuclear Receptor Coactivator 4Ncoa-4Androgen Receptor Coactivator 70 Kda Protein70 Kda Ar-Activator70 Kda Androgen Receptor CoactivatorAndrogen Receptor-Associated Protein Of 70 KdaFerritin Cargo Receptor Ncoa4Ret-Activating Protein Ele1 |
| Cellular Localisation | Cytoplasmic VesicleAutophagosomeAutolysosomeNucleusChromosome |
| Alternative Antibody Names | Anti-Nuclear Receptor Coactivator 4 antibodyAnti-Ncoa-4 antibodyAnti-Androgen Receptor Coactivator 70 Kda Protein antibodyAnti-70 Kda Ar-Activator antibodyAnti-70 Kda Androgen Receptor Coactivator antibodyAnti-Androgen Receptor-Associated Protein Of 70 Kda antibodyAnti-Ferritin Cargo Receptor Ncoa4 antibodyAnti-Ret-Activating Protein Ele1 antibodyAnti-NCOA4 antibodyAnti-ARA70 antibodyAnti-ELE1 antibodyAnti-RFG antibody |
Information sourced from Uniprot.org
