| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NCAM1 |
| Gene ID: | 4684 |
| Uniprot ID: | NCAM1_HUMAN |
| Immunogen Region: | 759-858 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 759-858 of human NCAM1/CD56 (NP_851996.2). |
| Immunogen Sequence: | LCGKAGPGAKGKDMEEGKAA FSKDESKEPIVEVRTEEERT PNHDGGKHTEPNETTPLTEP EKGPVEAKPECQETETKPAP AEVKTVPNDATQTKENESKA |
| Post Translational Modifications | Polysialylated at Asn-459 and Asn-488 by ST8SIA2 and ST8SIA4. Polysialylation modulates cell interactions by confering both attractive and repulsive properties that are highly regulated by ST8SIA2 and ST8SIA4. Polysialylation is formed on a-2,3-linked sialic acid of core glycans. |
| Function | This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. (Microbial infection) Acts as a receptor for rabies virus. (Microbial infection) Acts as a receptor for Zika virus. |
| Protein Name | Neural Cell Adhesion Molecule 1 N-Cam-1 Ncam-1 Cd Antigen Cd56 |
| Database Links | Reactome: R-HSA-3000178 Reactome: R-HSA-375165 Reactome: R-HSA-419037 Reactome: R-HSA-445144 Reactome: R-HSA-5673001 Reactome: R-HSA-877300 |
| Cellular Localisation | Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Cell Membrane Isoform 3: Cell Membrane Lipid-Anchor Gpi-Anchor Isoform 4: Cell Membrane Isoform 5: Secreted Isoform 6: Secreted |
| Alternative Antibody Names | Anti-Neural Cell Adhesion Molecule 1 antibody Anti-N-Cam-1 antibody Anti-Ncam-1 antibody Anti-Cd Antigen Cd56 antibody Anti-NCAM1 antibody Anti-NCAM antibody |
Information sourced from Uniprot.org