Anti-NAXE antibody (121-170 aa) (STJ91512)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human AIBP at the amino acid range 121-170
General Information
| Short Description | Rabbit polyclonal anti-NADPH-hydrate epimeraseHX epimerase (121-170 aa) for use in WB, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NAXE |
| Gene ID | 128240 |
| Uniprot ID | NNRE_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human AIBP at the amino acid range 121-170 |
| Immunogen Region | 121-170 aa |
| Specificity | AI-BP Polyclonal Antibody detects endogenous levels of AI-BP protein. |
Additional Info
| Post Translational Modifications | Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation. |
| Function | Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. |
| Protein Name | Nad(Ph-Hydrate EpimeraseApolipoprotein A-I-Binding ProteinAi-BpNad(Phx EpimeraseNaxeYjef N-Terminal Domain-Containing Protein 1Yjef_n1 |
| Database Links | Reactome: R-HSA-197264 |
| Cellular Localisation | MitochondrionSecretedIn SpermSecretion Gradually Increases During Capacitation |
| Alternative Antibody Names | Anti-Nad(Ph-Hydrate Epimerase antibodyAnti-Apolipoprotein A-I-Binding Protein antibodyAnti-Ai-Bp antibodyAnti-Nad(Phx Epimerase antibodyAnti-Naxe antibodyAnti-Yjef N-Terminal Domain-Containing Protein 1 antibodyAnti-Yjef_n1 antibodyAnti-NAXE antibodyAnti-AIBP antibodyAnti-APOA1BP antibodyAnti-YJEFN1 antibody |
Information sourced from Uniprot.org