| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NAXE (48-170) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NAXE |
| Gene ID: |
128240 |
| Uniprot ID: |
NNRE_HUMAN |
| Immunogen Region: |
48-170 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 48-170 of human NAXE (NP_658985.2). |
| Immunogen Sequence: |
DSEVMASTVVKYLSQEEAQA VDQELFNEYQFSVDQLMELA GLSCATAIAKAYPPTSMSRS PPTVLVICGPGNNGGDGLVC ARHLKLFGYEPTIYYPKRPN KPLFTALVTQCQKMDIPFLG EMP |
| Tissue Specificity | Ubiquitously expressed, with highest levels in kidney, heart and liver. Present in cerebrospinal fluid and urine but not in serum from healthy patients. Present in serum of sepsis patients (at protein level). |
| Post Translational Modifications | Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation. |
| Function | Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. |
| Protein Name | Nad(Ph-Hydrate EpimeraseApolipoprotein A-I-Binding ProteinAi-BpNad(Phx EpimeraseYjef N-Terminal Domain-Containing Protein 1Yjef_n1 |
| Database Links | Reactome: R-HSA-197264 |
| Cellular Localisation | MitochondrionSecretedIn SpermSecretion Gradually Increases During Capacitation |
| Alternative Antibody Names | Anti-Nad(Ph-Hydrate Epimerase antibodyAnti-Apolipoprotein A-I-Binding Protein antibodyAnti-Ai-Bp antibodyAnti-Nad(Phx Epimerase antibodyAnti-Yjef N-Terminal Domain-Containing Protein 1 antibodyAnti-Yjef_n1 antibodyAnti-NAXE antibodyAnti-AIBP antibodyAnti-APOA1BP antibodyAnti-YJEFN1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
