| Tissue Specificity | Widely expressed, with highest expression in parathyroid and pituitary glands, followed by adrenal gland and kidney, and lowest expression in leukocytes and mammary gland. |
| Post Translational Modifications | Isoform 1: Ubiquitinated, leading to its degradation by the proteasome. Isoform 2: Ubiquitinated, leading to its degradation by the proteasome. |
| Function | Methyltransferase that can methylate proteins and, to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'.ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. It however only plays a limited role in arsenic metabolism compared with AS3MT. |
| Protein Name | Methyltransferase N6amt1Hemk Methyltransferase Family Member 2M.hsahemk2pLysine N-Methyltransferase 9Methylarsonite Methyltransferase N6amt1Protein N(5-Glutamine Methyltransferase |
| Database Links | Reactome: R-HSA-156581Reactome: R-HSA-72764 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Methyltransferase N6amt1 antibodyAnti-Hemk Methyltransferase Family Member 2 antibodyAnti-M.hsahemk2p antibodyAnti-Lysine N-Methyltransferase 9 antibodyAnti-Methylarsonite Methyltransferase N6amt1 antibodyAnti-Protein N(5-Glutamine Methyltransferase antibodyAnti-N6AMT1 antibodyAnti-C21orf127 antibodyAnti-HEMK2 antibodyAnti-KMT9 antibodyAnti-PRED28 antibody |
Information sourced from Uniprot.org
