• Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using MYSM1 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of MCF7 cells using MYSM1 Polyclonal Antibody diluted at 1：2000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).
  • Western blot analysis of Hela lysis using MYSM1 antibody. Antibody was diluted at 1:2000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).
  • Western blot analysis of various cells using MYSM1 Polyclonal Antibody diluted at 1：2000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).

Anti-MYSM1 antibody (520-569) (STJ94322)

SKU:
STJ94322

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Deubiquitinase MYSM1 (520-569) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MYSM1
Gene ID: 114803
Uniprot ID: MYSM1_HUMAN
Immunogen Region: 520-569
Specificity: MYSM1 Polyclonal Antibody detects endogenous levels of MYSM1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from human MYSM1. AA range:520-569
Function Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response. Participates in the normal programming of B-cell responses to antigen after the maturation process. Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity. Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes. Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component. Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains. In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors. Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome.
Protein Name Deubiquitinase Mysm1
2a-Dub
Myb-Like - Swirm And Mpn Domain-Containing Protein 1
Database Links Reactome: R-HSA-5689901
Cellular Localisation Nucleus
Cytoplasm
Localizes To The Cytoplasm In Response To Bacterial Infection
Alternative Antibody Names Anti-Deubiquitinase Mysm1 antibody
Anti-2a-Dub antibody
Anti-Myb-Like - Swirm And Mpn Domain-Containing Protein 1 antibody
Anti-MYSM1 antibody
Anti-KIAA1915 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance