Anti-MYOCD antibody (200-280 aa) (STJ191768)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 200-280
General Information
| Short Description | Rabbit polyclonal anti-Myocardin (200-280 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MYOCD |
| Gene ID | 93649 |
| Uniprot ID | MYCD_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 200-280 |
| Immunogen Region | 200-280 aa |
| Specificity | MYCD Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Ubiquitinated.by STUB1/CHIP at the C-terminus, leading to its degradation by the proteasome. Phosphorylation by GSK3B is required for STUB1/CHIP-mediated ubiquitination. Phosphorylation negatively regulates the intrinsic myocardin transcriptional activity. Phosphorylated.by GSK3B. |
| Function | Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis). Positively regulates the transcription of genes involved in vascular smooth muscle contraction. |
| Protein Name | Myocardin |
| Database Links | Reactome: R-HSA-9733709 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Myocardin antibodyAnti-MYOCD antibodyAnti-MYCD antibody |
Information sourced from Uniprot.org