| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Matrix remodeling-associated protein 8 (42-92 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MXRA8 |
| Gene ID: |
54587 |
| Uniprot ID: |
MXRA8_HUMAN |
| Immunogen Region: |
42-92 aa |
| Specificity: |
This antibody detects endogenous levels of MXRA8 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human MXRA8 at the amino acid range 42-92 |
| Function | Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3. Mediates heterophilic cell-cell interactions in vitro. Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38. Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes. Stimulates formation of primary cilia in chondrocytes. Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH.may also promote signaling via the PTHLH/PTHrP pathway. Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis. Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells. Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK. May play a role in the maturation and maintenance of the blood-brain barrier. (Microbial infection) Contributes to arthritogenic alphavirus pathogenesis and acts as a receptor for these viruses. |
| Protein Name | Matrix Remodeling-Associated Protein 8Limitrin |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionTight JunctionCytoplasmCell ProjectionCilium MembraneNucleusPrimarily Localizes To The Cell MembraneDetected In The Cilium Of Primary ChondrocytesHighly Expressed At Areas Of Cell-Cell Contact And May Localize To Tight JunctionsAlso Found In The Nucleus Where It Is Detected In The Soluble (As Opposed To Chromatin-Bound) Fraction |
| Alternative Antibody Names | Anti-Matrix Remodeling-Associated Protein 8 antibodyAnti-Limitrin antibodyAnti-MXRA8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
